ON GLP-1 (OZEMPIC / WEGOVY / ZEPBOUND)· ⚗️ The Reset

GLP-1s change what your body needs from supplements.

The drug works. But eating 30–40% less means 30–40% fewer vitamins, minerals, and amino acids — right when your body is rebuilding its hormonal baseline.

Selene built this profile for women on semaglutide, tirzepatide, or liraglutide — because their nutritional needs are genuinely different, their hormonal profiles are shifting in real time, and the interactions with conditions like PCOS, perimenopause, or thyroid disease create a third layer of complexity that no generic GLP-1 supplement protocol addresses. The stack here covers the deficiency layer first, then adapts to your existing condition.

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“People on GLP-1 drugs eat an average of 30–40% fewer calories per day. Clinical nutrition reviews estimate that without deliberate supplementation, most GLP-1 users develop functional deficiencies in protein, B12, iron, zinc, and vitamin D within 3–6 months. These are the same nutrients that run the hormonal systems GLP-1 is trying to fix — making the drug less effective and harder to tolerate over time. There is also a category of urgency specific to women with PCOS: GLP-1 drugs restore ovulation in 50–65% of previously anovulatory PCOS women within months. If you assumed you were infertile, that assumption needs updating immediately.”

American Journal of Clinical Nutrition, 2025 / Fertility & Sterility RCT, 2025

YOUR PROFILE

⚗️

The Reset

On GLP-1 (Ozempic / Wegovy / Zepbound)

WHAT'S IN YOUR PACK

Essential amino acids (EAAs)10–15g daily
GLP-1 drugs cause 25–40% of total weight loss to come from lean mass (muscle), not fat — unless protein intake is deliberately maintained. EAAs, especially leucine, activate mTOR for muscle protein synthesis even in a caloric deficit. This is the single most important supplement for GLP-1 users.
Methylcobalamin B12 (sublingual)1000mcg
GLP-1 drugs slow gastric acid secretion. B12 absorption depends on intrinsic factor produced by stomach acid-stimulated parietal cells. Reduced gastric acid → impaired intrinsic factor → impaired B12 absorption. Sublingual bypasses the stomach entirely. B12 deficiency manifests as fatigue, brain fog, and nerve tingling — symptoms often misattributed to the drug itself.
Iron bisglycinate18mg
Women on GLP-1s who are still menstruating are at high risk for iron deficiency — they are losing iron monthly while eating significantly less iron-rich food. Iron bisglycinate is absorbed at 4× the rate of ferrous sulfate with far fewer GI side effects, which matters because GLP-1 already stresses the GI system. Ferritin below 30 ng/mL impairs thyroid conversion and ovarian function.
Zinc bisglycinate25mg
Zinc is required for ovarian steroidogenesis, thyroid hormone synthesis, and immune function. Reduced dietary intake on GLP-1s predictably drops zinc. Low zinc also worsens GLP-1 GI side effects (nausea, cramping) because zinc is essential for gut epithelial integrity. Bisglycinate form avoids the copper displacement seen with high-dose zinc sulfate.
Vitamin D3 + K2 (MK-7)4000 IU + 200mcg
Rapid weight loss releases fat-stored toxins and disrupts fat-soluble vitamin stores — D3, K2, A, and E. Vitamin D is particularly critical: it is required for ovarian follicle maturation, thyroid receptor sensitivity, and insulin signaling. K2 directs calcium to bones rather than arteries during the rapid bone-density changes that accompany significant weight loss. D deficiency is extremely common in people with obesity, and GLP-1 does not automatically fix it.
Thiamine (B1)100mg
This one is a safety issue, not just optimization. Wernicke's encephalopathy (a severe neurological thiamine deficiency) has been documented in bariatric surgery patients on similar caloric restriction and GI alteration profiles. GLP-1 drugs create analogous conditions: severe nausea reducing B1-rich food intake, vomiting causing B1 loss, and altered GI transit impairing absorption. B1 deficiency causes confusion, eye movement problems, and unsteady gait — symptoms sometimes mistaken for medication side effects.
Magnesium glycinate400mg
Reduced food intake drops dietary magnesium, which runs insulin signaling, sleep architecture, and cortisol regulation — the three systems GLP-1 is most trying to fix. Magnesium also reduces GLP-1-associated muscle cramps (extremely common, especially in legs). Glycinate form is gentler on a GLP-1-stressed GI system than citrate or oxide.
Probiotic blend (Lactobacillus + Bifidobacterium)10B CFU
GLP-1 drugs substantially alter gut motility and gastric pH — both of which reshape the gut microbiome. Specific Lactobacillus strains (rhamnosus, helveticus) upregulate endogenous GLP-1 secretion by L-cells in the colon, potentially extending and smoothing the drug's effects. Probiotics also reduce GLP-1-associated nausea and bloating in clinical reports.

The Reset stack addresses the universal GLP-1 deficiency layer. Your condition-specific protocol (PCOS, perimenopause, thyroid, etc.) layers on top — the quiz merges both when you indicate you're on a GLP-1 drug. EAAs and thiamine are unique to this profile and not in other Selene stacks.

“I was six months into semaglutide, losing weight but feeling terrible — brain fog, exhausted, always cold. My labs showed B12 at the bottom of the range, ferritin at 14, and vitamin D at 18. No one had warned me this was coming. The Reset stack fixed what the drug was breaking.”

Maya R.
PCOS + GLP-1 · Chicago

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